2eo6

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[[Image:2eo6.png|left|200px]]
 
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{{STRUCTURE_2eo6| PDB=2eo6 | SCENE= }}
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==Solution structure of the SH2 domain from mouse B-cell linker protein BLNK==
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<StructureSection load='2eo6' size='340' side='right'caption='[[2eo6]]' scene=''>
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===Solution structure of the SH2 domain from mouse B-cell linker protein BLNK===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2eo6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EO6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eo6 OCA], [https://pdbe.org/2eo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eo6 RCSB], [https://www.ebi.ac.uk/pdbsum/2eo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eo6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eo6 TOPSAN]</span></td></tr>
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[[2eo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EO6 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLNK_MOUSE BLNK_MOUSE] Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.<ref>PMID:9705962</ref> <ref>PMID:12761551</ref> <ref>PMID:18369315</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eo6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eo6 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hayashi, F.]]
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[[Category: Hayashi F]]
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[[Category: Kurosaki, C.]]
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[[Category: Kurosaki C]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Sano R]]
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[[Category: Sano, R.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M.]]
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[[Category: B-cell adapter containing sh2 domain protein]]
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[[Category: B-cell adapter containing src homology 2 domain protein]]
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[[Category: Cytoplasmic adapter protein]]
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[[Category: Lymphocyte antigen 57]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Sh2]]
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[[Category: Signaling protein]]
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[[Category: Slp-65]]
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[[Category: Src homology 2 domain-containing leukocyte protein of 65 kda]]
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[[Category: Structural genomic]]
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Current revision

Solution structure of the SH2 domain from mouse B-cell linker protein BLNK

PDB ID 2eo6

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