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2atv

From Proteopedia

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[[Image:2atv.png|left|200px]]
 
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{{STRUCTURE_2atv| PDB=2atv | SCENE= }}
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==The crystal structure of human RERG in the GDP bound state==
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<StructureSection load='2atv' size='340' side='right'caption='[[2atv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===The crystal structure of human RERG in the GDP bound state===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2atv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ATV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[2atv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATV OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2atv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2atv OCA], [https://pdbe.org/2atv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2atv RCSB], [https://www.ebi.ac.uk/pdbsum/2atv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2atv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RERG_HUMAN RERG_HUMAN] Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/at/2atv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2atv ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Burgess, N.]]
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[[Category: Arrowsmith C]]
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[[Category: Delft, F von.]]
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[[Category: Burgess N]]
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[[Category: Doyle, D.]]
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[[Category: Doyle D]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Elkins, J.]]
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[[Category: Elkins J]]
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[[Category: Gileadi, O.]]
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[[Category: Gileadi O]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Salah E]]
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[[Category: Salah, E.]]
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[[Category: Schoch G]]
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[[Category: Schoch, G.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Turnbull AP]]
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[[Category: Turnbull, A P.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Gdp/gtp binding]]
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[[Category: Gtp hydrolysis]]
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[[Category: Rerg]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

The crystal structure of human RERG in the GDP bound state

PDB ID 2atv

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