2atv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2atv" [edit=sysop:move=sysop])
Current revision (07:29, 23 August 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2atv.png|left|200px]]
 
-
{{STRUCTURE_2atv| PDB=2atv | SCENE= }}
+
==The crystal structure of human RERG in the GDP bound state==
-
 
+
<StructureSection load='2atv' size='340' side='right'caption='[[2atv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
===The crystal structure of human RERG in the GDP bound state===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2atv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ATV FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
==About this Structure==
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
[[2atv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATV OCA].
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2atv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2atv OCA], [https://pdbe.org/2atv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2atv RCSB], [https://www.ebi.ac.uk/pdbsum/2atv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2atv ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RERG_HUMAN RERG_HUMAN] Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/at/2atv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2atv ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Large Structures]]
-
[[Category: Burgess, N.]]
+
[[Category: Arrowsmith C]]
-
[[Category: Delft, F von.]]
+
[[Category: Burgess N]]
-
[[Category: Doyle, D.]]
+
[[Category: Doyle D]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards A]]
-
[[Category: Elkins, J.]]
+
[[Category: Elkins J]]
-
[[Category: Gileadi, O.]]
+
[[Category: Gileadi O]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Salah E]]
-
[[Category: Salah, E.]]
+
[[Category: Schoch G]]
-
[[Category: Schoch, G.]]
+
[[Category: Sundstrom M]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Turnbull AP]]
-
[[Category: Turnbull, A P.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
[[Category: Von Delft F]]
-
[[Category: Gdp/gtp binding]]
+
-
[[Category: Gtp hydrolysis]]
+
-
[[Category: Rerg]]
+
-
[[Category: Sgc]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+

Current revision

The crystal structure of human RERG in the GDP bound state

PDB ID 2atv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2atv"
Personal tools