2d3m

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[[Image:2d3m.png|left|200px]]
 
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{{STRUCTURE_2d3m| PDB=2d3m | SCENE= }}
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==Pentaketide chromone synthase complexed with coenzyme A==
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<StructureSection load='2d3m' size='340' side='right'caption='[[2d3m]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2d3m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aloe_arborescens Aloe arborescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D3M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d3m OCA], [https://pdbe.org/2d3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d3m RCSB], [https://www.ebi.ac.uk/pdbsum/2d3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d3m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PCS_ALOAR PCS_ALOAR] Catalyzes the iterative condensations of 5 molecules of malonyl-CoA to produce a pentaketide 5,7-dihydroxy-2-methylchromone.<ref>PMID:15686354</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d3/2d3m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d3m ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structures of a wild-type and a mutant PCS, a novel plant type III polyketide synthase from a medicinal plant, Aloe arborescens, were solved at 1.6 A resolution. The crystal structures revealed that the pentaketide-producing wild-type and the octaketide-producing M207G mutant shared almost the same overall folding, and that the large-to-small substitution dramatically increases the volume of the polyketide-elongation tunnel by opening a gate to two hidden pockets behind the active site of the enzyme. The chemically inert active site residue 207 thus controls the number of condensations of malonyl-CoA, solely depending on the steric bulk of the side chain. These findings not only provided insight into the polyketide formation reaction, but they also suggested strategies for the engineered biosynthesis of polyketides.
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===Pentaketide chromone synthase complexed with coenzyme A===
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Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens.,Morita H, Kondo S, Oguro S, Noguchi H, Sugio S, Abe I, Kohno T Chem Biol. 2007 Apr;14(4):359-69. PMID:17462571<ref>PMID:17462571</ref>
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{{ABSTRACT_PUBMED_17462571}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2d3m" style="background-color:#fffaf0;"></div>
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[[2d3m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aloe_arborescens Aloe arborescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D3M OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:017462571</ref><references group="xtra"/>
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</StructureSection>
[[Category: Aloe arborescens]]
[[Category: Aloe arborescens]]
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[[Category: Abe, I.]]
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[[Category: Large Structures]]
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[[Category: Kohno, T.]]
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[[Category: Abe I]]
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[[Category: Kondo, S.]]
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[[Category: Kohno T]]
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[[Category: Morita, H.]]
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[[Category: Kondo S]]
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[[Category: Noguchi, H.]]
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[[Category: Morita H]]
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[[Category: Oguro, S.]]
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[[Category: Noguchi H]]
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[[Category: Sugio, S.]]
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[[Category: Oguro S]]
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[[Category: Chalcone synthase]]
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[[Category: Sugio S]]
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[[Category: Pentaketide chromone synthase]]
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[[Category: Polyketide synthase]]
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[[Category: Transferase]]
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Current revision

Pentaketide chromone synthase complexed with coenzyme A

PDB ID 2d3m

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