2a91

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[[Image:2a91.png|left|200px]]
 
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{{STRUCTURE_2a91| PDB=2a91 | SCENE= }}
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==Crystal structure of ErbB2 domains 1-3==
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<StructureSection load='2a91' size='340' side='right'caption='[[2a91]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A91 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a91 OCA], [https://pdbe.org/2a91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a91 RCSB], [https://www.ebi.ac.uk/pdbsum/2a91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a91 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/2a91_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a91 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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ErbB2 does not bind ligand, yet appears to be the major signaling partner for other ErbB receptors by forming heteromeric complexes with ErbB1, ErbB3, or ErbB4. The crystal structure of residues 1-509 of ErbB2 at 2.5 A resolution reveals an activated conformation similar to that of the EGFR when complexed with ligand and very different from that seen in the unactivated forms of ErbB3 or EGFR. The structure explains the inability of ErbB2 to bind known ligands and suggests why ErbB2 fails to form homodimers. Together, the data suggest a model in which ErbB2 is already in the activated conformation and ready to interact with other ligand-activated ErbB receptors.
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===Crystal structure of ErbB2 domains 1-3===
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The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors.,Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Kofler M, Jorissen RN, Nice EC, Burgess AW, Ward CW Mol Cell. 2003 Feb;11(2):495-505. PMID:12620236<ref>PMID:12620236</ref>
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{{ABSTRACT_PUBMED_12620236}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2a91" style="background-color:#fffaf0;"></div>
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[[2a91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A91 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:012620236</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Adams TE]]
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[[Category: Adams, T E.]]
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[[Category: Burgess AW]]
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[[Category: Burgess, A W.]]
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[[Category: Elleman TC]]
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[[Category: Elleman, T C.]]
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[[Category: Garrett TPJ]]
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[[Category: Garrett, T P.J.]]
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[[Category: Jorissen RN]]
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[[Category: Jorissen, R N.]]
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[[Category: Kofler M]]
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[[Category: Kofler, M.]]
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[[Category: Lou M]]
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[[Category: Lou, M.]]
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[[Category: Lovrecz GO]]
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[[Category: Lovrecz, G O.]]
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[[Category: McKern NM]]
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[[Category: McKern, N M.]]
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[[Category: Nice EC]]
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[[Category: Nice, E C.]]
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[[Category: Cell-surface receptor]]
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[[Category: Membrane protein]]
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[[Category: Signaling protein]]
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[[Category: Transferase]]
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[[Category: Tyrosine kinase receptor]]
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Current revision

Crystal structure of ErbB2 domains 1-3

PDB ID 2a91

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