1uz1

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[[Image:1uz1.jpg|left|200px]]<br /><applet load="1uz1" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1uz1, resolution 2.00&Aring;" />
 
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'''FAMILY 1 B-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH ISOFAGOMINE LACTAM'''<br />
 
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==About this Structure==
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==Family 1 b-glucosidase from Thermotoga maritima in complex with isofagomine lactam==
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1UZ1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=IFL:'>IFL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] Known structural/functional Site: <scene name='pdbsite=AC1:Ifl+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ1 OCA].
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<StructureSection load='1uz1' size='340' side='right'caption='[[1uz1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1uz1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UZ1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IFL:(3S,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PIPERIDIN-2-ONE'>IFL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz1 OCA], [https://pdbe.org/1uz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uz1 RCSB], [https://www.ebi.ac.uk/pdbsum/1uz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uz1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BGLA_THEMA BGLA_THEMA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/1uz1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uz1 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis., Vincent F, Gloster TM, Macdonald J, Morland C, Stick RV, Dias FM, Prates JA, Fontes CM, Gilbert HJ, Davies GJ, Chembiochem. 2004 Nov 5;5(11):1596-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15515081 15515081]
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*[[Beta-glucosidase 3D structures|Beta-glucosidase 3D structures]]
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[[Category: Beta-glucosidase]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Davies, G J.]]
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[[Category: Davies GJ]]
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[[Category: Gloster, T M.]]
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[[Category: Gloster TM]]
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[[Category: Macdonald, J.]]
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[[Category: Macdonald J]]
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[[Category: Stick, R V.]]
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[[Category: Stick RV]]
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[[Category: IFL]]
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[[Category: enzyme]]
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[[Category: family gh1]]
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[[Category: glucoside hydrolysis]]
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[[Category: hydrolase]]
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[[Category: isofagomine lactam]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:29:57 2008''
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Current revision

Family 1 b-glucosidase from Thermotoga maritima in complex with isofagomine lactam

PDB ID 1uz1

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