2dk9
From Proteopedia
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| - | [[Image:2dk9.png|left|200px]] | ||
| - | + | ==Solution structure of Calponin Homology domain of Human MICAL-1== | |
| - | + | <StructureSection load='2dk9' size='340' side='right'caption='[[2dk9]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2dk9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DK9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dk9 OCA], [https://pdbe.org/2dk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dk9 RCSB], [https://www.ebi.ac.uk/pdbsum/2dk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dk9 ProSAT]</span></td></tr> |
| - | [[2dk9]] is a 1 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/MICA1_HUMAN MICA1_HUMAN] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.<ref>PMID:18305261</ref> <ref>PMID:21864500</ref> |
| - | < | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/2dk9_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dk9 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Dai | + | [[Category: Large Structures]] |
| - | [[Category: Shi | + | [[Category: Dai H]] |
| - | [[Category: Sun | + | [[Category: Shi Y]] |
| - | [[Category: Wu | + | [[Category: Sun H]] |
| - | [[Category: Xiong | + | [[Category: Wu J]] |
| - | [[Category: Zhang | + | [[Category: Xiong S]] |
| - | + | [[Category: Zhang J]] | |
| - | + | ||
Current revision
Solution structure of Calponin Homology domain of Human MICAL-1
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Categories: Homo sapiens | Large Structures | Dai H | Shi Y | Sun H | Wu J | Xiong S | Zhang J
