2b6b
From Proteopedia
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| - | [[Image:2b6b.png|left|200px]] | ||
| - | + | ==Cryo EM structure of Dengue complexed with CRD of DC-SIGN== | |
| - | + | <SX load='2b6b' size='340' side='right' viewer='molstar' caption='[[2b6b]], [[Resolution|resolution]] 25.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2b6b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus Dengue virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B6B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 25Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6b OCA], [https://pdbe.org/2b6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b6b RCSB], [https://www.ebi.ac.uk/pdbsum/2b6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b6b ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2b6b]] is a 4 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/Q9WDA7_9FLAV Q9WDA7_9FLAV] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859] | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b6b_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b6b ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </SX> | ||
[[Category: Dengue virus]] | [[Category: Dengue virus]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bator-Kelly | + | [[Category: Large Structures]] |
| - | [[Category: Battisti | + | [[Category: Bator-Kelly CM]] |
| - | [[Category: Chipman | + | [[Category: Battisti AJ]] |
| - | [[Category: Gregorio | + | [[Category: Chipman PR]] |
| - | [[Category: Hendrickson | + | [[Category: Gregorio G]] |
| - | [[Category: Kuhn | + | [[Category: Hendrickson WA]] |
| - | [[Category: Pokidysheva | + | [[Category: Kuhn RJ]] |
| - | [[Category: Rossmann | + | [[Category: Pokidysheva E]] |
| - | [[Category: Zhang | + | [[Category: Rossmann MG]] |
| - | + | [[Category: Zhang Y]] | |
| - | + | ||
| - | + | ||
Current revision
Cryo EM structure of Dengue complexed with CRD of DC-SIGN
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