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2bw1

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[[Image:2bw1.png|left|200px]]
 
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{{STRUCTURE_2bw1| PDB=2bw1 | SCENE= }}
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==Iron-bound crystal structure of Dps-like peroxide resistance protein (Dpr) from Streptococcus suis.==
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<StructureSection load='2bw1' size='340' side='right'caption='[[2bw1]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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===IRON-BOUND CRYSTAL STRUCTURE OF DPS-LIKE PEROXIDE RESISTANCE PROTEIN (DPR) FROM STREPTOCOCCUS SUIS.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2bw1]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_suis Streptococcus suis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BW1 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16997323}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bw1 OCA], [https://pdbe.org/2bw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bw1 RCSB], [https://www.ebi.ac.uk/pdbsum/2bw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bw1 ProSAT]</span></td></tr>
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[[2bw1]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_suis Streptococcus suis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BW1 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DPS_STRSU DPS_STRSU] Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). It binds and incorporates Fe(2+) iron. Is responsible for hydrogen peroxide resistance. Does not bind DNA.
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<ref group="xtra">PMID:016997323</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/2bw1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bw1 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptococcus suis]]
[[Category: Streptococcus suis]]
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[[Category: Finne, J.]]
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[[Category: Finne J]]
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[[Category: Haataja, S.]]
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[[Category: Haataja S]]
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[[Category: Kauko, A.]]
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[[Category: Kauko A]]
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[[Category: Papageorgiou, A C.]]
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[[Category: Papageorgiou AC]]
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[[Category: Pulliainen, A.]]
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[[Category: Pulliainen A]]
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[[Category: Dpr]]
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[[Category: Dps-family]]
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[[Category: Ferritin-like]]
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[[Category: Ferroxidase]]
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[[Category: Iron-binding]]
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[[Category: Peroxide resistance]]
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Current revision

Iron-bound crystal structure of Dps-like peroxide resistance protein (Dpr) from Streptococcus suis.

PDB ID 2bw1

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OCA

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