2dsi

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[[Image:2dsi.png|left|200px]]
 
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{{STRUCTURE_2dsi| PDB=2dsi | SCENE= }}
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==Crystal structure of Glu171 to Arg mutant of Diphthine synthase==
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<StructureSection load='2dsi' size='340' side='right'caption='[[2dsi]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal structure of Glu171 to Arg mutant of Diphthine synthase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dsi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[2dsi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSI OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsi OCA], [https://pdbe.org/2dsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsi RCSB], [https://www.ebi.ac.uk/pdbsum/2dsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsi ProSAT], [https://www.topsan.org/Proteins/RSGI/2dsi TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dsi ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Diphthine synthase|Diphthine synthase]]
*[[Diphthine synthase|Diphthine synthase]]
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[[Category: Diphthine synthase]]
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== References ==
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[[Category: Pyrococcus horikoshii]]
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<references/>
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[[Category: Kumarevel, T S.]]
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__TOC__
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[[Category: Kunishima, N.]]
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</StructureSection>
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[[Category: Matsuura, Y.]]
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[[Category: Large Structures]]
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[[Category: Mizutani, H.]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Ponnuswamy, M N.]]
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[[Category: Kumarevel TS]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Kunishima N]]
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[[Category: Saraboji, K.]]
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[[Category: Malathy Sony SM]]
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[[Category: Sony, S M.Malathy.]]
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[[Category: Matsuura Y]]
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[[Category: Methyltransferase]]
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[[Category: Mizutani H]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Ponnuswamy MN]]
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[[Category: Nppsfa]]
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[[Category: Saraboji K]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Glu171 to Arg mutant of Diphthine synthase

PDB ID 2dsi

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