2b25

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[[Image:2b25.png|left|200px]]
 
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{{STRUCTURE_2b25| PDB=2b25 | SCENE= }}
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==Human putative tRNA(1-methyladenosine)methyltransferase==
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<StructureSection load='2b25' size='340' side='right'caption='[[2b25]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Human putative tRNA(1-methyladenosine)methyltransferase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b25]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B25 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[2b25]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B25 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b25 OCA], [https://pdbe.org/2b25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b25 RCSB], [https://www.ebi.ac.uk/pdbsum/2b25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b25 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TR61B_HUMAN TR61B_HUMAN] Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codons UCA, UCU, UCG or UCC).<ref>PMID:23097428</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b25_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b25 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith C]]
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[[Category: Dong, A.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A.]]
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[[Category: Dong A]]
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[[Category: Loppnau, P.]]
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[[Category: Edwards A]]
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[[Category: Plotnikov, A N.]]
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[[Category: Loppnau P]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Plotnikov AN]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Zeng, H.]]
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[[Category: Zeng H]]
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[[Category: Methyl transferase]]
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[[Category: Sam]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Human putative tRNA(1-methyladenosine)methyltransferase

PDB ID 2b25

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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