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2e3r

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[[Image:2e3r.png|left|200px]]
 
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{{STRUCTURE_2e3r| PDB=2e3r | SCENE= }}
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==Crystal structure of CERT START domain in complex with C18-ceramide (P1)==
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<StructureSection load='2e3r' size='340' side='right'caption='[[2e3r]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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===Crystal structure of CERT START domain in complex with C18-ceramide (P1)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2e3r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E3R FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18184806}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=18C:N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE'>18C</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3r OCA], [https://pdbe.org/2e3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e3r RCSB], [https://www.ebi.ac.uk/pdbsum/2e3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e3r ProSAT]</span></td></tr>
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[[2e3r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3R OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
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<ref group="xtra">PMID:018184806</ref><references group="xtra"/>
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== Function ==
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[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/2e3r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e3r ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hanada, K.]]
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[[Category: Large Structures]]
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[[Category: Kato, R.]]
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[[Category: Hanada K]]
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[[Category: Kudo, N.]]
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[[Category: Kato R]]
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[[Category: Kumagai, K.]]
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[[Category: Kudo N]]
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[[Category: Nishijima, M.]]
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[[Category: Kumagai K]]
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[[Category: Wakatsuki, S.]]
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[[Category: Nishijima M]]
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[[Category: Ceramide transfer]]
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[[Category: Wakatsuki S]]
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[[Category: Cert]]
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[[Category: Lipid transfer protein]]
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[[Category: Lipid transport]]
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Current revision

Crystal structure of CERT START domain in complex with C18-ceramide (P1)

PDB ID 2e3r

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