2eta

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[[Image:2eta.png|left|200px]]
 
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{{STRUCTURE_2eta| PDB=2eta | SCENE= }}
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==Crystal structure of the ankyrin repeat domain of the TRPV2==
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<StructureSection load='2eta' size='340' side='right'caption='[[2eta]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2eta]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ETA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ETA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eta OCA], [https://pdbe.org/2eta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eta RCSB], [https://www.ebi.ac.uk/pdbsum/2eta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eta ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRPV2_RAT TRPV2_RAT] Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).<ref>PMID:10201375</ref> <ref>PMID:15249591</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/et/2eta_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eta ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the ankyrin repeat domain of the TRPV2===
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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{{ABSTRACT_PUBMED_16809337}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2eta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ETA OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:016809337</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Gaudet, R.]]
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[[Category: Gaudet R]]
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[[Category: Jin, X.]]
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[[Category: Jin X]]
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[[Category: Ankyrin repeat domain]]
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[[Category: Transport protein]]
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[[Category: Trpv2]]
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Current revision

Crystal structure of the ankyrin repeat domain of the TRPV2

PDB ID 2eta

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OCA

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