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2de2

From Proteopedia

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[[Image:2de2.png|left|200px]]
 
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{{STRUCTURE_2de2| PDB=2de2 | SCENE= }}
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==Crystal structure of desulfurization enzyme DSZB==
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<StructureSection load='2de2' size='340' side='right'caption='[[2de2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Crystal structure of desulfurization enzyme DSZB===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2de2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._IGTS8 Rhodococcus sp. IGTS8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DE2 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16891315}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2de2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2de2 OCA], [https://pdbe.org/2de2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2de2 RCSB], [https://www.ebi.ac.uk/pdbsum/2de2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2de2 ProSAT]</span></td></tr>
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[[2de2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DE2 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DSZB_RHOSG DSZB_RHOSG] Catalyzes the third and final step of the '4S' desulfurization pathway that removes covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds. Oxidizes 2-(2'-hydroxyphenyl)benzene sulphinate (HBPS) to 2-hydroxybiphenyl (HBP) plus sulfite (PubMed:7961424, PubMed:7574582, PubMed:9634856, PubMed:9308179, PubMed:31545606). The rate-limiting step of the '4S' desulfurization pathway (PubMed:9308179, PubMed:31545606). The pathway substrate specificity has been augmented using mutagenesis, however no mutations allowed use of alkylated thiophenes (PubMed:11823208).<ref>PMID:11823208</ref> <ref>PMID:31545606</ref> <ref>PMID:7574582</ref> <ref>PMID:7961424</ref> <ref>PMID:9308179</ref> <ref>PMID:9634856</ref>
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<ref group="xtra">PMID:016891315</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: 2'-hydroxybiphenyl-2-sulfinate desulfinase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Rhodococcus sp.]]
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Check<jmol>
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[[Category: Izumi, Y.]]
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<jmolCheckbox>
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[[Category: Lee, W C.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/2de2_consurf.spt"</scriptWhenChecked>
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[[Category: Matsubara, T.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Ohshiro, T.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Tanokura, M.]]
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</jmolCheckbox>
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[[Category: Alpha-beta]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2de2 ConSurf].
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[[Category: Hydrolase]]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rhodococcus sp. IGTS8]]
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[[Category: Izumi Y]]
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[[Category: Lee WC]]
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[[Category: Matsubara T]]
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[[Category: Ohshiro T]]
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[[Category: Tanokura M]]

Current revision

Crystal structure of desulfurization enzyme DSZB

PDB ID 2de2

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