2e5q

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[[Image:2e5q.png|left|200px]]
 
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{{STRUCTURE_2e5q| PDB=2e5q | SCENE= }}
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==Solution structure of the TUDOR domain of PHD finger protein 19, isoform b [Homo sapiens]==
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<StructureSection load='2e5q' size='340' side='right'caption='[[2e5q]]' scene=''>
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===Solution structure of the TUDOR domain of PHD finger protein 19, isoform b [Homo sapiens]===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2e5q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5q OCA], [https://pdbe.org/2e5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5q RCSB], [https://www.ebi.ac.uk/pdbsum/2e5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5q ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5q TOPSAN]</span></td></tr>
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[[2e5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5Q OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PHF19_HUMAN PHF19_HUMAN] Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.<ref>PMID:15563832</ref> <ref>PMID:21143197</ref> <ref>PMID:23104054</ref> <ref>PMID:23160351</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5q ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dang, W.]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Dang W]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Muto, Y.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Muto Y]]
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[[Category: Shirouzu, M.]]
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[[Category: Shirouzu M]]
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[[Category: Terada, T.]]
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[[Category: Terada T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Isoform b]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Phd finger protein 19]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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[[Category: Tudor domain]]
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Current revision

Solution structure of the TUDOR domain of PHD finger protein 19, isoform b [Homo sapiens]

PDB ID 2e5q

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