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2cud

From Proteopedia

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[[Image:2cud.png|left|200px]]
 
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{{STRUCTURE_2cud| PDB=2cud | SCENE= }}
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==Solution structure of the SH3 domain of the human SRC-like adopter protein (SLAP)==
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<StructureSection load='2cud' size='340' side='right'caption='[[2cud]]' scene=''>
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===Solution structure of the SH3 domain of the human SRC-like adopter protein (SLAP)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2cud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cud OCA], [https://pdbe.org/2cud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cud RCSB], [https://www.ebi.ac.uk/pdbsum/2cud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cud ProSAT], [https://www.topsan.org/Proteins/RSGI/2cud TOPSAN]</span></td></tr>
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[[2cud]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUD OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SLAP1_HUMAN SLAP1_HUMAN] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.<ref>PMID:11696592</ref> <ref>PMID:10449770</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cud_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cud ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: Nameki, N.]]
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[[Category: Koshiba S]]
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[[Category: Ohnishi, S.]]
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[[Category: Nameki N]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Ohnishi S]]
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[[Category: Sato, M.]]
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[[Category: Sato M]]
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[[Category: Tochio, N.]]
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[[Category: Tochio N]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Negative mitogenesis regulator]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Solution structure of the SH3 domain of the human SRC-like adopter protein (SLAP)

PDB ID 2cud

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