2d8u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2d8u" [edit=sysop:move=sysop])
Current revision (11:35, 22 May 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2d8u.png|left|200px]]
 
-
{{STRUCTURE_2d8u| PDB=2d8u | SCENE= }}
+
==Solution structure of the B-box domain of the human tripartite motif-containing 63 protein==
 +
<StructureSection load='2d8u' size='340' side='right'caption='[[2d8u]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2d8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8U FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8u OCA], [https://pdbe.org/2d8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8u RCSB], [https://www.ebi.ac.uk/pdbsum/2d8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8u ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8u TOPSAN]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/2d8u_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d8u ConSurf].
 +
<div style="clear:both"></div>
-
===Solution structure of the B-box domain of the human tripartite motif-containing 63 protein===
+
==See Also==
-
 
+
*[[Mur ligase|Mur ligase]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[2d8u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8U OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Inoue, M.]]
+
[[Category: Large Structures]]
-
[[Category: Kigawa, T.]]
+
[[Category: Inoue M]]
-
[[Category: Koshiba, S.]]
+
[[Category: Kigawa T]]
-
[[Category: Miyamoto, K.]]
+
[[Category: Koshiba S]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Miyamoto K]]
-
[[Category: Tomizawa, T.]]
+
[[Category: Tomizawa T]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yokoyama S]]
-
[[Category: Iris ring finger protein]]
+
-
[[Category: Ligase]]
+
-
[[Category: Murf1]]
+
-
[[Category: Muscle-specific ring finger protein 1]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Ring finger protein 28]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Striated muscle ring zinc finger protein]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Trim63]]
+
-
[[Category: Tripartite motif-containing 63]]
+
-
[[Category: Zf-b_box]]
+

Current revision

Solution structure of the B-box domain of the human tripartite motif-containing 63 protein

PDB ID 2d8u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2d8u"
Personal tools