2ck4

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[[Image:2ck4.png|left|200px]]
 
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{{STRUCTURE_2ck4| PDB=2ck4 | SCENE= }}
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==Solution Structure of aOSK1==
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<StructureSection load='2ck4' size='340' side='right'caption='[[2ck4]]' scene=''>
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===SOLUTION STRUCTURE OF AOSK1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ck4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthochirus_scrobiculosus Orthochirus scrobiculosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CK4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ck4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck4 OCA], [https://pdbe.org/2ck4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ck4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ck4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ck4 ProSAT]</span></td></tr>
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[[2ck4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CK4 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAX37_ORTSC KAX37_ORTSC] Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1]<ref>PMID:15588251</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2ck4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ck4 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Potassium channel toxin|Potassium channel toxin]]
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*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
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[[Category: Alphonse, S.]]
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== References ==
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[[Category: Bernard, C.]]
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<references/>
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[[Category: Darbon, H.]]
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__TOC__
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[[Category: Mouhat, S.]]
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</StructureSection>
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[[Category: Sabatier, J M.]]
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[[Category: Large Structures]]
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[[Category: Ion channel blocker]]
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[[Category: Orthochirus scrobiculosus]]
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[[Category: Ion channel inhibitor]]
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[[Category: Alphonse S]]
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[[Category: Ionic channel inhibitor]]
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[[Category: Bernard C]]
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[[Category: Neurotoxin]]
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[[Category: Darbon H]]
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[[Category: Osk1]]
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[[Category: Mouhat S]]
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[[Category: Potassium channel inhibitor]]
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[[Category: Sabatier JM]]
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[[Category: Scorpio toxin]]
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[[Category: Toxin]]
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Current revision

Solution Structure of aOSK1

PDB ID 2ck4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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