2a5w

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[[Image:2a5w.png|left|200px]]
 
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{{STRUCTURE_2a5w| PDB=2a5w | SCENE= }}
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==Crystal structure of the oxidized gamma-subunit of the dissimilatory sulfite reductase (DsrC) from Archaeoglobus fulgidus==
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<StructureSection load='2a5w' size='340' side='right'caption='[[2a5w]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2a5w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A5W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a5w OCA], [https://pdbe.org/2a5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a5w RCSB], [https://www.ebi.ac.uk/pdbsum/2a5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a5w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O28055_ARCFU O28055_ARCFU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/2a5w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a5w ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray structure of the gamma-subunit of the dissimilatory sulfite reductase (DsrC) from Archaeoglobus fulgidus was determined at 1.12 and 2.1A resolution, in the two crystal forms named DsrC(nat) and DsrC(ox) the latter being cocrystallized with the oxidizing agent tert-butyl hydroperoxide. The fold corresponds to that of the homologous protein from Pyrobaculum aerophilum but is significantly more compact. The most interesting, highly conserved C-terminal arm adopts a well-defined conformation in A. fulgidus DsrC in contrast to the completely disordered conformation in P. aerophilum DsrC. The functional relevance of both conformations and of a potentially redox-active disulfide bond between the strictly invariant Cys103 and Cys114 are discussed.
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===Crystal structure of the oxidized gamma-subunit of the dissimilatory sulfite reductase (DsrC) from Archaeoglobus fulgidus===
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X-ray structure of the gamma-subunit of a dissimilatory sulfite reductase: fixed and flexible C-terminal arms.,Mander GJ, Weiss MS, Hedderich R, Kahnt J, Ermler U, Warkentin E FEBS Lett. 2005 Aug 29;579(21):4600-4. PMID:16098517<ref>PMID:16098517</ref>
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{{ABSTRACT_PUBMED_16098517}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2a5w" style="background-color:#fffaf0;"></div>
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[[2a5w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_dsm_4304 Archaeoglobus fulgidus dsm 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5W OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016098517</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Archaeoglobus fulgidus dsm 4304]]
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[[Category: Archaeoglobus fulgidus DSM 4304]]
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[[Category: Ermler, U.]]
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[[Category: Large Structures]]
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[[Category: Hedderich, R.]]
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[[Category: Ermler U]]
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[[Category: Kahnt, J.]]
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[[Category: Hedderich R]]
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[[Category: Mander, G J.]]
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[[Category: Kahnt J]]
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[[Category: Warkentin, E.]]
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[[Category: Mander GJ]]
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[[Category: Weiss, M S.]]
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[[Category: Warkentin E]]
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[[Category: Orthogonal helix bundle]]
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[[Category: Weiss MS]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of the oxidized gamma-subunit of the dissimilatory sulfite reductase (DsrC) from Archaeoglobus fulgidus

PDB ID 2a5w

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