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1v8f

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[[Image:1v8f.jpg|left|200px]]<br /><applet load="1v8f" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1v8f, resolution 1.90&Aring;" />
 
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'''Crystal Structure of Pantoate-beta-Alanine (Pantothenate Synthetase) from Thermus Thermophilus HB8'''<br />
 
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==About this Structure==
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==Crystal Structure of Pantoate-beta-Alanine (Pantothenate Synthetase) from Thermus Thermophilus HB8==
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1V8F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=144:'>144</scene>, <scene name='pdbligand=P6G:'>P6G</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pantoate--beta-alanine_ligase Pantoate--beta-alanine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.1 6.3.2.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8F OCA].
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<StructureSection load='1v8f' size='340' side='right'caption='[[1v8f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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[[Category: Pantoate--beta-alanine ligase]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1v8f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V8F FirstGlance]. <br>
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[[Category: Thermus thermophilus]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Bagautdinov, B.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8f OCA], [https://pdbe.org/1v8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v8f RCSB], [https://www.ebi.ac.uk/pdbsum/1v8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v8f ProSAT], [https://www.topsan.org/Proteins/RSGI/1v8f TOPSAN]</span></td></tr>
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[[Category: Tahirov, T H.]]
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</table>
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[[Category: 144]]
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== Function ==
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[[Category: CL]]
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[https://www.uniprot.org/uniprot/PANC_THET8 PANC_THET8] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity).[HAMAP-Rule:MF_00158]
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[[Category: GOL]]
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== Evolutionary Conservation ==
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[[Category: P6G]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: dimer]]
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Check<jmol>
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[[Category: ligase]]
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<jmolCheckbox>
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[[Category: riken structural genomics/proteomics initiative]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v8/1v8f_consurf.spt"</scriptWhenChecked>
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[[Category: rossmann fold]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: rsgi]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: structural genomics]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v8f ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:32:39 2008''
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==See Also==
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*[[Pantothenate synthetase|Pantothenate synthetase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Thermus thermophilus]]
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[[Category: Bagautdinov B]]
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[[Category: Tahirov TH]]

Current revision

Crystal Structure of Pantoate-beta-Alanine (Pantothenate Synthetase) from Thermus Thermophilus HB8

PDB ID 1v8f

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