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2a8l

From Proteopedia

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[[Image:2a8l.png|left|200px]]
 
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{{STRUCTURE_2a8l| PDB=2a8l | SCENE= }}
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==Crystal structure of Human Taspase1 (T234A mutant)==
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<StructureSection load='2a8l' size='340' side='right'caption='[[2a8l]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal structure of Human Taspase1 (T234A mutant)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2a8l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A8L FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16216576}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a8l OCA], [https://pdbe.org/2a8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a8l RCSB], [https://www.ebi.ac.uk/pdbsum/2a8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a8l ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2a8l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A8L OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/TASP1_HUMAN TASP1_HUMAN] Protease involved in MLL processing and, consequently, in the correct expression of the early HOXA gene cluster.
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:016216576</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/2a8l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a8l ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dunn, B M.]]
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[[Category: Large Structures]]
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[[Category: Khan, J A.]]
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[[Category: Dunn BM]]
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[[Category: Tong, L.]]
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[[Category: Khan JA]]
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[[Category: Asparaginase]]
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[[Category: Tong L]]
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[[Category: Glycosylasparaginase]]
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[[Category: Hydrolase]]
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[[Category: Leukemia]]
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[[Category: Mll]]
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[[Category: Taspase1]]
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Current revision

Crystal structure of Human Taspase1 (T234A mutant)

PDB ID 2a8l

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OCA

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