2bkf

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[[Image:2bkf.png|left|200px]]
 
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{{STRUCTURE_2bkf| PDB=2bkf | SCENE= }}
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==Structure of the PB1 domain of NBR1==
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<StructureSection load='2bkf' size='340' side='right'caption='[[2bkf]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2bkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BKF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bkf OCA], [https://pdbe.org/2bkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bkf RCSB], [https://www.ebi.ac.uk/pdbsum/2bkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bkf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NBR1_HUMAN NBR1_HUMAN] Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.<ref>PMID:19250911</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The scaffold protein NBR1 is involved in signal transmission downstream of the serine/protein kinase from the giant muscle protein titin. Its N-terminal Phox and Bem1p (PB1) domain plays a critical role in mediating protein-protein interactions with both titin kinase and with another scaffold protein, p62. We have determined the crystal structure of the PB1 domain of NBR1 at 1.55A resolution. It reveals a type-A PB1 domain with two negatively charged residue clusters. We provide a structural perspective on the involvement of NBR1 in the titin kinase signalling pathway.
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===STRUCTURE OF THE PB1 DOMAIN OF NBR1===
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Crystal structure of the PB1 domain of NBR1.,Muller S, Kursula I, Zou P, Wilmanns M FEBS Lett. 2006 Jan 9;580(1):341-4. Epub 2005 Dec 19. PMID:16376336<ref>PMID:16376336</ref>
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{{ABSTRACT_PUBMED_16376336}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2bkf" style="background-color:#fffaf0;"></div>
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[[2bkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKF OCA].
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kursula, I.]]
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[[Category: Large Structures]]
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[[Category: Mueller, S.]]
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[[Category: Kursula I]]
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[[Category: Wilmanns, M.]]
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[[Category: Mueller S]]
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[[Category: Interaction domain]]
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[[Category: Wilmanns M]]
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[[Category: Nbr1]]
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[[Category: Pb1 domain]]
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[[Category: Zinc-finger]]
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[[Category: Zinc-finger protein]]
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Current revision

Structure of the PB1 domain of NBR1

PDB ID 2bkf

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