2d3j

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[[Image:2d3j.png|left|200px]]
 
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{{STRUCTURE_2d3j| PDB=2d3j | SCENE= }}
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==NMR structure of the WIF domain from human WIF-1==
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<StructureSection load='2d3j' size='340' side='right'caption='[[2d3j]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2d3j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D3J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d3j OCA], [https://pdbe.org/2d3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d3j RCSB], [https://www.ebi.ac.uk/pdbsum/2d3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d3j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WIF1_HUMAN WIF1_HUMAN] Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d3/2d3j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d3j ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The human Wnt-binding protein Wnt-inhibitory factor-1 (WIF-1) comprises an N-terminal WIF module followed by five EGF-like repeats. Here we report the three-dimensional structure of the WIF domain of WIF-1 determined by NMR spectroscopy. The fold consists of an eight-stranded beta-sandwich reminiscent of the immunoglobulin fold. Residual detergent (Brij-35) used in the refolding protocol was found to bind tightly to the WIF domain. The binding site was identified by intermolecular nuclear Overhauser effects observed between the WIF domain and the alkyl chain of the detergent. The results point to a possible role of WIF domains as a recognition motif of Wnt and Drosophila Hedgehog proteins that are activated by palmitoylation.
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===NMR structure of the WIF domain from human WIF-1===
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NMR structure of the WIF domain of the human Wnt-inhibitory factor-1.,Liepinsh E, Banyai L, Patthy L, Otting G J Mol Biol. 2006 Mar 31;357(3):942-50. Epub 2006 Jan 31. PMID:16476441<ref>PMID:16476441</ref>
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{{ABSTRACT_PUBMED_16476441}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2d3j" style="background-color:#fffaf0;"></div>
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[[2d3j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D3J OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016476441</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Banyai, L.]]
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[[Category: Large Structures]]
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[[Category: Liepinsh, E.]]
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[[Category: Banyai L]]
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[[Category: Otting, G.]]
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[[Category: Liepinsh E]]
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[[Category: Patthy, L.]]
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[[Category: Otting G]]
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[[Category: Palmitoyl group]]
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[[Category: Patthy L]]
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[[Category: Recognition domain]]
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[[Category: Signaling protein inhibitor]]
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Current revision

NMR structure of the WIF domain from human WIF-1

PDB ID 2d3j

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