2d2a

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[[Image:2d2a.png|left|200px]]
 
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{{STRUCTURE_2d2a| PDB=2d2a | SCENE= }}
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==Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters==
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<StructureSection load='2d2a' size='340' side='right'caption='[[2d2a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2d2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D2A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d2a OCA], [https://pdbe.org/2d2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d2a RCSB], [https://www.ebi.ac.uk/pdbsum/2d2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d2a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SUFA_ECOLI SUFA_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/2d2a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d2a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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IscA and SufA are paralogous proteins that play crucial roles in the biosynthesis of Fe-S clusters, perhaps through a mechanism involving transient Fe-S cluster formation. We have determined the crystal structure of E. coli SufA at 2.7A resolution. SufA exists as a homodimer, in contrast to the tetrameric organization of IscA. Furthermore, a C-terminal segment containing two essential cysteine residues (Cys-Gly-Cys), which is disordered in the IscA structure, is clearly visible in one molecule (the alpha1 subunit) of the SufA homodimer. Although this segment is disordered in the other molecule (the alpha2 subunit), computer modeling of this segment based on the well-defined conformation of alpha1 subunit suggests that the four cysteine residues (Cys114 and Cys116 in each subunit) in the Cys-Gly-Cys motif are positioned in close proximity at the dimer interface. The arrangement of these cysteines together with the nearby Glu118 in SufA dimer may allow coordination of an Fe-S cluster and/or an Fe atom.
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===Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters===
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Crystal structure of Escherichia coli SufA involved in biosynthesis of iron-sulfur clusters: implications for a functional dimer.,Wada K, Hasegawa Y, Gong Z, Minami Y, Fukuyama K, Takahashi Y FEBS Lett. 2005 Dec 5;579(29):6543-8. Epub 2005 Nov 15. PMID:16298366<ref>PMID:16298366</ref>
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{{ABSTRACT_PUBMED_16298366}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2d2a" style="background-color:#fffaf0;"></div>
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[[2d2a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2A OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016298366</ref><references group="xtra"/>
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Fukuyama, K.]]
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[[Category: Large Structures]]
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[[Category: Gong, Z.]]
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[[Category: Fukuyama K]]
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[[Category: Hasegawa, Y.]]
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[[Category: Gong Z]]
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[[Category: Minami, Y.]]
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[[Category: Hasegawa Y]]
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[[Category: Takahashi, Y.]]
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[[Category: Minami Y]]
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[[Category: Wada, K.]]
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[[Category: Takahashi Y]]
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[[Category: Iron]]
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[[Category: Wada K]]
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[[Category: Iron-sulfur cluster]]
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[[Category: Isca]]
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[[Category: Metal transport]]
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[[Category: Suf]]
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[[Category: Sufa]]
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[[Category: Yadr]]
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Current revision

Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters

PDB ID 2d2a

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