2ask

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[[Image:2ask.png|left|200px]]
 
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{{STRUCTURE_2ask| PDB=2ask | SCENE= }}
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==Structure of human Artemin==
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<StructureSection load='2ask' size='340' side='right'caption='[[2ask]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [https://pdbe.org/2ask PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [https://www.ebi.ac.uk/pdbsum/2ask PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ask ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARTN_HUMAN ARTN_HUMAN] Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.<ref>PMID:9883723</ref> <ref>PMID:10583383</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2ask_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ask ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Artemin (ART) promotes the growth of developing peripheral neurons by signaling through a multicomponent receptor complex comprised of a transmembrane tyrosine kinase receptor (cRET) and a specific glycosylphosphatidylinositol-linked co-receptor (GFRalpha3). Glial cell line-derived neurotrophic factor (GDNF) signals through a similar ternary complex but requires heparan sulfate proteoglycans (HSPGs) for full activity. HSPG has not been demonstrated as a requirement for ART signaling. We crystallized ART in the presence of sulfate and solved its structure by isomorphous replacement. The structure reveals ordered sulfate anions bound to arginine residues in the pre-helix and amino-terminal regions that were organized in a triad arrangement characteristic of heparan sulfate. Three residues in the pre-helix were singly or triply substituted with glutamic acid, and the resulting proteins were shown to have reduced heparin-binding affinity that is partly reflected in their ability to activate cRET. This study suggests that ART binds HSPGs and identifies residues that may be involved in HSPG binding.
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===Structure of human Artemin===
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Artemin crystal structure reveals insights into heparan sulfate binding.,Silvian L, Jin P, Carmillo P, Boriack-Sjodin PA, Pelletier C, Rushe M, Gong B, Sah D, Pepinsky B, Rossomando A Biochemistry. 2006 Jun 6;45(22):6801-12. PMID:16734417<ref>PMID:16734417</ref>
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{{ABSTRACT_PUBMED_16734417}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2ask" style="background-color:#fffaf0;"></div>
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[[2ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016734417</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boriack-Sjodin, P A.]]
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[[Category: Large Structures]]
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[[Category: Carmillo, P.]]
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[[Category: Boriack-Sjodin PA]]
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[[Category: Gong, B J.]]
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[[Category: Carmillo P]]
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[[Category: Jin, P.]]
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[[Category: Gong BJ]]
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[[Category: Pelletier, C.]]
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[[Category: Jin P]]
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[[Category: Pepinsky, B.]]
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[[Category: Pelletier C]]
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[[Category: Rossomando, A.]]
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[[Category: Pepinsky B]]
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[[Category: Rushe, M.]]
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[[Category: Rossomando A]]
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[[Category: Sah, D.]]
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[[Category: Rushe M]]
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[[Category: Silvian, L.]]
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[[Category: Sah D]]
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[[Category: Glial cell derived family ligand]]
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[[Category: Silvian L]]
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[[Category: Hormone-growth factor complex]]
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[[Category: Neurotrphoic growth factor]]
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[[Category: Sulfate]]
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Current revision

Structure of human Artemin

PDB ID 2ask

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