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2dpk

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[[Image:2dpk.png|left|200px]]
 
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{{STRUCTURE_2dpk| PDB=2dpk | SCENE= }}
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==The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger==
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<StructureSection load='2dpk' size='340' side='right'caption='[[2dpk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dpk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canlf Canlf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DPK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GAI:GUANIDINE'>GAI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dpk OCA], [https://pdbe.org/2dpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dpk RCSB], [https://www.ebi.ac.uk/pdbsum/2dpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dpk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/NAC1_CANFA NAC1_CANFA]] Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dp/2dpk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dpk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Na+/Ca2+ exchanger is a plasma membrane protein that regulates intracellular Ca2+ levels in cardiac myocytes. Transport activity is governed by Ca2+, and the primary Ca2+ sensor (CBD1) is located in a large cytoplasmic loop connecting two transmembrane helices. The binding of Ca2+ to the CBD1 sensory domain results in conformational changes that stimulate the exchanger to extrude Ca2+. Here, we present a crystal structure of CBD1 at 2.5A resolution, which reveals a novel Ca2+ binding site consisting of four Ca2+ ions arranged in a tight planar cluster. This intricate coordination pattern for a Ca2+ binding cluster is indicative of a highly sensitive Ca2+ sensor and may represent a general platform for Ca2+ sensing.
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===The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger===
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The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif.,Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J J Biol Chem. 2006 Aug 4;281(31):21577-81. Epub 2006 Jun 14. PMID:16774926<ref>PMID:16774926</ref>
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{{ABSTRACT_PUBMED_16774926}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2dpk" style="background-color:#fffaf0;"></div>
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[[2dpk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DPK OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016774926</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Canis lupus familiaris]]
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[[Category: Canlf]]
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[[Category: Abramson, J.]]
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[[Category: Large Structures]]
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[[Category: Sawaya, M.]]
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[[Category: Abramson, J]]
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[[Category: Sawaya, M]]
[[Category: Beta-bulge]]
[[Category: Beta-bulge]]
[[Category: Beta-sandwich]]
[[Category: Beta-sandwich]]

Current revision

The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger

PDB ID 2dpk

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