2eci

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[[Image:2eci.png|left|200px]]
 
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{{STRUCTURE_2eci| PDB=2eci | SCENE= }}
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==Solution structure of the RING domain of the human TNF receptor-associated factor 6 protein==
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<StructureSection load='2eci' size='340' side='right'caption='[[2eci]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2eci]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eci OCA], [https://pdbe.org/2eci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eci RCSB], [https://www.ebi.ac.uk/pdbsum/2eci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eci ProSAT], [https://www.topsan.org/Proteins/RSGI/2eci TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2eci_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eci ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the RING domain of the human TNF receptor-associated factor 6 protein===
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==See Also==
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*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[2eci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECI OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Harada, T.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Harada T]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: Miyamoto, K.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Miyamoto K]]
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[[Category: Sato, M.]]
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[[Category: Sato M]]
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[[Category: Watanabe, S.]]
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[[Category: Watanabe S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Metal binding protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Ring domain]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tnf receptor-associated factor 6]]
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[[Category: Traf6]]
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[[Category: Zinc-binding domain]]
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Current revision

Solution structure of the RING domain of the human TNF receptor-associated factor 6 protein

PDB ID 2eci

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OCA

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