2ed9

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[[Image:2ed9.png|left|200px]]
 
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{{STRUCTURE_2ed9| PDB=2ed9 | SCENE= }}
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==Solution structure of the third fibronectin type III domain of human Netrin receptor DCC==
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<StructureSection load='2ed9' size='340' side='right'caption='[[2ed9]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ed9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ED9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ed9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed9 OCA], [https://pdbe.org/2ed9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ed9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ed9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ed9 TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[https://omim.org/entry/157600 157600]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2ed9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ed9 ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the third fibronectin type III domain of human Netrin receptor DCC===
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==See Also==
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*[[Netrin receptor|Netrin receptor]]
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== References ==
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==About this Structure==
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<references/>
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[[2ed9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED9 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kigawa, T.]]
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[[Category: Large Structures]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Koshiba S]]
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[[Category: Tochio, N.]]
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[[Category: Tochio N]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Apoptosis]]
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[[Category: Colorectal cancer suppressor]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tumor suppressor protein dcc]]
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Current revision

Solution structure of the third fibronectin type III domain of human Netrin receptor DCC

PDB ID 2ed9

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