2d5u

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[[Image:2d5u.png|left|200px]]
 
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{{STRUCTURE_2d5u| PDB=2d5u | SCENE= }}
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==Solution structure of the N-terminal portion of the PUB domain of mouse peptide:N-glycanase==
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<StructureSection load='2d5u' size='340' side='right'caption='[[2d5u]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2d5u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D5U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d5u OCA], [https://pdbe.org/2d5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d5u RCSB], [https://www.ebi.ac.uk/pdbsum/2d5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d5u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NGLY1_MOUSE NGLY1_MOUSE] Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.<ref>PMID:11562482</ref> <ref>PMID:12606569</ref> <ref>PMID:15358861</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/2d5u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d5u ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the N-terminal portion of the PUB domain of mouse peptide:N-glycanase===
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==See Also==
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*[[Peptide N-glycanase|Peptide N-glycanase]]
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== References ==
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==About this Structure==
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<references/>
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[[2d5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D5U OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hirao, T.]]
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[[Category: Hirao T]]
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[[Category: Kato, K.]]
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[[Category: Kato K]]
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[[Category: Sasakawa, H.]]
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[[Category: Sasakawa H]]
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[[Category: Suzuki, T.]]
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[[Category: Suzuki T]]
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[[Category: Yamaguchi, Y.]]
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[[Category: Yamaguchi Y]]
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[[Category: Hydrolase]]
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[[Category: Pngase]]
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Current revision

Solution structure of the N-terminal portion of the PUB domain of mouse peptide:N-glycanase

PDB ID 2d5u

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Proteopedia Page Contributors and Editors (what is this?)

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