2bi0

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[[Image:2bi0.png|left|200px]]
 
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{{STRUCTURE_2bi0| PDB=2bi0 | SCENE= }}
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==RV0216, A conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdogfold==
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<StructureSection load='2bi0' size='340' side='right'caption='[[2bi0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2bi0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BI0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi0 OCA], [https://pdbe.org/2bi0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bi0 RCSB], [https://www.ebi.ac.uk/pdbsum/2bi0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bi0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P96398_MYCTO P96398_MYCTO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/2bi0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bi0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Mycobacterium tuberculosis genome contains about 4000 genes, of which approximately a third code for proteins of unknown function or are classified as conserved hypothetical proteins. We have determined the three-dimensional structure of one of these, the rv0216 gene product, which has been shown to be essential for M. tuberculosis growth in vivo. The structure exhibits the greatest similarity to bacterial and eukaryotic hydratases that catalyse the R-specific hydration of 2-enoyl coenzyme A. However, only part of the catalytic machinery is conserved in Rv0216 and it showed no activity for the substrate crotonyl-CoA. The structure of Rv0216 allows us to assign new functional annotations to a family of seven other M. tuberculosis proteins, a number if which are essential for bacterial survival during infection and growth.
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===RV0216, A CONSERVED HYPOTHETICAL PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS THAT IS ESSENTIAL FOR BACTERIAL SURVIVAL DURING INFECTION, HAS A DOUBLE HOTDOGFOLD===
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Rv0216, a conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdog fold.,Castell A, Johansson P, Unge T, Jones TA, Backbro K Protein Sci. 2005 Jul;14(7):1850-62. PMID:15987908<ref>PMID:15987908</ref>
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{{ABSTRACT_PUBMED_15987908}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2bi0" style="background-color:#fffaf0;"></div>
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[[2bi0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI0 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015987908</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Large Structures]]
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[[Category: Backbro, K.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Castell, A.]]
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[[Category: Backbro K]]
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[[Category: Johansson, P.]]
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[[Category: Castell A]]
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[[Category: Jones, T A.]]
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[[Category: Johansson P]]
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[[Category: Unge, T.]]
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[[Category: Jones TA]]
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[[Category: Conserved hypothetical]]
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[[Category: Unge T]]
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[[Category: Hotdog-fold]]
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[[Category: Hypothetical protein]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Rv0216]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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Current revision

RV0216, A conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdogfold

PDB ID 2bi0

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