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2di7

From Proteopedia

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[[Image:2di7.png|left|200px]]
 
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{{STRUCTURE_2di7| PDB=2di7 | SCENE= }}
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==Solution structure of the filamin domain from human BK158_1 protein==
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<StructureSection load='2di7' size='340' side='right'caption='[[2di7]]' scene=''>
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===Solution structure of the filamin domain from human BK158_1 protein===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2di7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DI7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2di7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di7 OCA], [https://pdbe.org/2di7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2di7 RCSB], [https://www.ebi.ac.uk/pdbsum/2di7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2di7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2di7 TOPSAN]</span></td></tr>
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[[2di7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI7 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLGT2_HUMAN PLGT2_HUMAN] Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001).<ref>PMID:30127001</ref> <ref>PMID:34411563</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/2di7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2di7 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Koshiba S]]
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[[Category: Tomizawa, T.]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Beta-sandwich]]
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[[Category: Filamin domain]]
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[[Category: Immunoglobulin-like fold]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Structural protein]]
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Current revision

Solution structure of the filamin domain from human BK158_1 protein

PDB ID 2di7

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