2drp

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[[Image:2drp.png|left|200px]]
 
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{{STRUCTURE_2drp| PDB=2drp | SCENE= }}
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==THE CRYSTAL STRUCTURE OF A TWO ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER/DNA RECOGNITION==
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<StructureSection load='2drp' size='340' side='right'caption='[[2drp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===THE CRYSTAL STRUCTURE OF A TWO ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER/DNA RECOGNITION===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2drp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DRP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_8247159}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2drp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2drp OCA], [https://pdbe.org/2drp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2drp RCSB], [https://www.ebi.ac.uk/pdbsum/2drp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2drp ProSAT]</span></td></tr>
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[[2drp]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DRP OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/TTKB_DROME TTKB_DROME] Binds to a number of sites in the transcriptional regulatory region of ftz. Isoform beta is required to repress inappropriate segmentation gene transcription and repress genes incompatible with development of photoreceptor cell fates. Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en. Inhibits Trl-dependent activation of eve. May bind to the region AGGGC/TGG. Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk. A second method of degradation exists that is phyl-independent, this is mediated by recognition of motifs in the C-terminus of ttk.<ref>PMID:2104801</ref> <ref>PMID:8223261</ref> <ref>PMID:8504931</ref> <ref>PMID:12384587</ref> <ref>PMID:17962185</ref>
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<ref group="xtra">PMID:008247159</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/2drp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2drp ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Chapman, L.]]
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[[Category: Large Structures]]
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[[Category: Fairall, L.]]
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[[Category: Chapman L]]
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[[Category: Finch, J T.]]
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[[Category: Fairall L]]
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[[Category: Rhodes, D.]]
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[[Category: Finch JT]]
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[[Category: Schwabe, J W.R.]]
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[[Category: Rhodes D]]
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[[Category: Double helix]]
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[[Category: Schwabe JWR]]
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[[Category: Protein-dna complex]]
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[[Category: Transcription-dna complex]]
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Current revision

THE CRYSTAL STRUCTURE OF A TWO ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER/DNA RECOGNITION

PDB ID 2drp

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