2b29

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2b29" [edit=sysop:move=sysop])
Current revision (09:15, 14 February 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2b29.png|left|200px]]
 
-
{{STRUCTURE_2b29| PDB=2b29 | SCENE= }}
+
==N-terminal domain of the RPA70 subunit of human replication protein A.==
 +
<StructureSection load='2b29' size='340' side='right'caption='[[2b29]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2b29]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B29 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b29 OCA], [https://pdbe.org/2b29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b29 RCSB], [https://www.ebi.ac.uk/pdbsum/2b29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b29 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b29_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b29 ConSurf].
 +
<div style="clear:both"></div>
-
===N-terminal domain of the RPA70 subunit of human replication protein A.===
+
==See Also==
-
 
+
*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
-
{{ABSTRACT_PUBMED_16234232}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[2b29]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B29 OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:016234232</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Ayed, A.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Ayed A]]
-
[[Category: Bochkareva, E.]]
+
[[Category: Bochkarev A]]
-
[[Category: Kaustov, L.]]
+
[[Category: Bochkareva E]]
-
[[Category: Milner, J.]]
+
[[Category: Kaustov L]]
-
[[Category: Okorokov, A.]]
+
[[Category: Milner J]]
-
[[Category: Replication]]
+
[[Category: Okorokov A]]

Current revision

N-terminal domain of the RPA70 subunit of human replication protein A.

PDB ID 2b29

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b29"
Personal tools