2akh

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Current revision (09:13, 14 February 2024) (edit) (undo)
 
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[[Image:2akh.png|left|200px]]
 
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{{STRUCTURE_2akh| PDB=2akh | SCENE= }}
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==Normal mode-based flexible fitted coordinates of a non-translocating SecYEG protein-conducting channel into the cryo-EM map of a SecYEG-nascent chain-70S ribosome complex from E. coli==
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<SX load='2akh' size='340' side='right' viewer='molstar' caption='[[2akh]], [[Resolution|resolution]] 14.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2akh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AKH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 14.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2akh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2akh OCA], [https://pdbe.org/2akh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2akh RCSB], [https://www.ebi.ac.uk/pdbsum/2akh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2akh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SECG_ECOLI SECG_ECOLI] Subunit of the protein translocation channel SecYEG. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true it also results in FtsH-mediated degradation of SecY. Treatment with antibiotics that block translation elongation such as chloramphenicol also leads to degradation of SecY and SecE but not SecG.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/2akh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2akh ConSurf].
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<div style="clear:both"></div>
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===Normal mode-based flexible fitted coordinates of a non-translocating SecYEG protein-conducting channel into the cryo-EM map of a SecYEG-nascent chain-70S ribosome complex from E. coli===
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==See Also==
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*[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]]
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{{ABSTRACT_PUBMED_16292303}}
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__TOC__
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</SX>
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==About this Structure==
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[[2akh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKH OCA].
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==Reference==
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<ref group="xtra">PMID:016292303</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Ban, N.]]
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[[Category: Large Structures]]
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[[Category: Frank, J.]]
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[[Category: Ban N]]
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[[Category: III, C L.Brooks.]]
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[[Category: Brooks III CL]]
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[[Category: Jenni, S.]]
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[[Category: Frank J]]
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[[Category: Mitra, K M.]]
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[[Category: Jenni S]]
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[[Category: Schaffitzel, C.]]
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[[Category: Mitra KM]]
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[[Category: Shaikh, T.]]
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[[Category: Schaffitzel C]]
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[[Category: Tama, F.]]
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[[Category: Shaikh T]]
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[[Category: Protein transport]]
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[[Category: Tama F]]
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[[Category: Translocation]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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Current revision

Normal mode-based flexible fitted coordinates of a non-translocating SecYEG protein-conducting channel into the cryo-EM map of a SecYEG-nascent chain-70S ribosome complex from E. coli

2akh, resolution 14.90Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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