2d0o

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[[Image:2d0o.png|left|200px]]
 
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{{STRUCTURE_2d0o| PDB=2d0o | SCENE= }}
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==Structure of diol dehydratase-reactivating factor complexed with ADP and Mg2+==
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<StructureSection load='2d0o' size='340' side='right'caption='[[2d0o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Strcuture of diol dehydratase-reactivating factor complexed with ADP and Mg2+===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2d0o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_oxytoca Klebsiella oxytoca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D0O FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16338403}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d0o OCA], [https://pdbe.org/2d0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d0o RCSB], [https://www.ebi.ac.uk/pdbsum/2d0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d0o ProSAT]</span></td></tr>
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[[2d0o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_oxytoca Klebsiella oxytoca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D0O OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DDRA_KLEOK DDRA_KLEOK] Large subunit of the diol dehydratase-reactivating factor (DDR), which reactivates suicidally inhibited adenosylcobalamin-dependent diol dehydratase (DD, pddA, pddB, pddC). DDR acts as a chaperone, reactivating inactivated DD holoenzyme in the presence of ATP, Mg(2+) and free adenosylcobalamin (AdoCbl), by mediating the exchange of the tightly bound damaged cofactor AdoCbl for a free intact one (PubMed:10529189, PubMed:9405397, PubMed:9920879, PubMed:17916188, PubMed:18586770, PubMed:21040475). Reactivation takes place in two steps: ADP-dependent cobalamin release, then ATP-dependent dissociation of the DD apoenzyme-DDR complex. DDR has weak ATPase activity which is required for DD reactivation (PubMed:10529189, PubMed:17916188, PubMed:21040475). This subunit contains the adenosine nucleotide binding site (PubMed:16338403). Activates glycerol-inactivated, O2-inactivated holoenzyme and inactivated enzyme-cyanocobalamin complex (PubMed:9920879). Also reactivates glycerol-inactivated hologlycerol dehydratase, a DD isozyme (PubMed:17916188).<ref>PMID:10529189</ref> <ref>PMID:16338403</ref> <ref>PMID:17916188</ref> <ref>PMID:18586770</ref> <ref>PMID:21040475</ref> <ref>PMID:9405397</ref> <ref>PMID:9920879</ref>
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<ref group="xtra">PMID:016338403</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/2d0o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d0o ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Klebsiella oxytoca]]
[[Category: Klebsiella oxytoca]]
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[[Category: Hieda, N.]]
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[[Category: Large Structures]]
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[[Category: Higuchi, Y.]]
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[[Category: Hieda N]]
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[[Category: Mori, K.]]
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[[Category: Higuchi Y]]
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[[Category: Shibata, N.]]
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[[Category: Mori K]]
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[[Category: Toraya, T.]]
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[[Category: Shibata N]]
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[[Category: Yamanishi, M.]]
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[[Category: Toraya T]]
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[[Category: Chaperone]]
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[[Category: Yamanishi M]]

Current revision

Structure of diol dehydratase-reactivating factor complexed with ADP and Mg2+

PDB ID 2d0o

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