2kuo

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m (Protected "2kuo" [edit=sysop:move=sysop])
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[[Image:2kuo.png|left|200px]]
 
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{{STRUCTURE_2kuo| PDB=2kuo | SCENE= }}
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==Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response==
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<StructureSection load='2kuo' size='340' side='right'caption='[[2kuo]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kuo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KUO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kuo OCA], [https://pdbe.org/2kuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kuo RCSB], [https://www.ebi.ac.uk/pdbsum/2kuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kuo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APLF_HUMAN APLF_HUMAN] Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.<ref>PMID:17396150</ref> <ref>PMID:17353262</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/2kuo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kuo ConSurf].
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<div style="clear:both"></div>
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===Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response===
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==See Also==
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*[[Apurinic/apyrimidinic endonuclease 3D structures|Apurinic/apyrimidinic endonuclease 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[2kuo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUO OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cheung, M.]]
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[[Category: Large Structures]]
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[[Category: Fenton, A.]]
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[[Category: Cheung M]]
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[[Category: Ikura, M.]]
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[[Category: Fenton A]]
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[[Category: Koch, C A.]]
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[[Category: Ikura M]]
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[[Category: Li, G Y.]]
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[[Category: Koch CA]]
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[[Category: McCulloch, R D.]]
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[[Category: Li GY]]
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[[Category: Meng, L.]]
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[[Category: McCulloch RD]]
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[[Category: Adp-ribose]]
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[[Category: Meng L]]
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[[Category: Adp-ribosylation]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Zinc-finger]]
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Current revision

Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response

PDB ID 2kuo

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