2jtu
From Proteopedia
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| - | [[Image:2jtu.png|left|200px]] | ||
| - | + | ==NMR structure of iota-RXIA(38)== | |
| - | + | <StructureSection load='2jtu' size='340' side='right'caption='[[2jtu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2jtu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JTU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtu OCA], [https://pdbe.org/2jtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jtu RCSB], [https://www.ebi.ac.uk/pdbsum/2jtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtu ProSAT]</span></td></tr> |
| - | [[2jtu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTU OCA]. | + | </table> |
| - | [[Category: Norton, R | + | == Function == |
| - | [[Category: Wei, D | + | [[https://www.uniprot.org/uniprot/CI1BA_CONRA CI1BA_CONRA]] Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.<ref>PMID:17696362</ref> <ref>PMID:18486102</ref> |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtu_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jtu ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Norton, R]] | ||
| + | [[Category: Wei, D]] | ||
[[Category: Bromination]] | [[Category: Bromination]] | ||
[[Category: D-amino acid]] | [[Category: D-amino acid]] | ||
Current revision
NMR structure of iota-RXIA(38)
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Categories: Large Structures | Norton, R | Wei, D | Bromination | D-amino acid | Hydroxylation | Iota-rxia | Neurotoxin | Secreted | Toxin
