2guc

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[[Image:2guc.png|left|200px]]
 
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{{STRUCTURE_2guc| PDB=2guc | SCENE= }}
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==Crystal structure of a complex of griffithsin with mannose at 1.78 A resolution.==
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<StructureSection load='2guc' size='340' side='right'caption='[[2guc]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2guc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Griffithsia Griffithsia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GUC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2guc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2guc OCA], [https://pdbe.org/2guc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2guc RCSB], [https://www.ebi.ac.uk/pdbsum/2guc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2guc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRFIN_GRISQ GRFIN_GRISQ]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/2guc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2guc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of griffithsin, an antiviral lectin from the red alga Griffithsia sp., was solved and refined at 1.3 A resolution for the free protein and 0.94 A for a complex with mannose. Griffithsin molecules form a domain-swapped dimer, in which two beta strands of one molecule complete a beta prism consisting of three four-stranded sheets, with an approximate 3-fold axis, of another molecule. The structure of each monomer bears close resemblance to jacalin-related lectins, but its dimeric structure is unique. The structures of complexes of griffithsin with mannose and N-acetylglucosamine defined the locations of three almost identical carbohydrate binding sites on each monomer. We have also shown that griffithsin is a potent inhibitor of the coronavirus responsible for severe acute respiratory syndrome (SARS). Antiviral potency of griffithsin is likely due to the presence of multiple, similar sugar binding sites that provide redundant attachment points for complex carbohydrate molecules present on viral envelopes.
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===Crystal structure of a complex of griffithsin with mannose at 1.78 A resolution.===
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Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.,Ziolkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A Structure. 2006 Jul;14(7):1127-35. PMID:16843894<ref>PMID:16843894</ref>
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{{ABSTRACT_PUBMED_16843894}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2guc" style="background-color:#fffaf0;"></div>
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[[2guc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Griffithsia Griffithsia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GUC OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016843894</ref><references group="xtra"/>
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</StructureSection>
[[Category: Griffithsia]]
[[Category: Griffithsia]]
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[[Category: Wlodawer, A.]]
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[[Category: Large Structures]]
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[[Category: Ziolkowska, N E.]]
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[[Category: Wlodawer A]]
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[[Category: Domain swapping]]
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[[Category: Ziolkowska NE]]
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[[Category: Griffithsin]]
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[[Category: Hiv]]
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[[Category: Lectin]]
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[[Category: Mannose binding]]
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[[Category: Sar]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal structure of a complex of griffithsin with mannose at 1.78 A resolution.

PDB ID 2guc

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