2khn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:46, 1 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2khn.png|left|200px]]
 
-
{{STRUCTURE_2khn| PDB=2khn | SCENE= }}
+
==NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.==
 +
<StructureSection load='2khn' size='340' side='right'caption='[[2khn]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2khn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHN FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khn OCA], [https://pdbe.org/2khn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khn RCSB], [https://www.ebi.ac.uk/pdbsum/2khn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khn ProSAT], [https://www.topsan.org/Proteins/NESGC/2khn TOPSAN]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kh/2khn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2khn ConSurf].
 +
<div style="clear:both"></div>
-
===NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.===
+
==See Also==
-
 
+
*[[Intersectin|Intersectin]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[2khn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Acton, T B.]]
+
[[Category: Large Structures]]
-
[[Category: Everett, J K.]]
+
[[Category: Acton TB]]
-
[[Category: Foote, E L.]]
+
[[Category: Everett JK]]
-
[[Category: Garcia, E.]]
+
[[Category: Foote EL]]
-
[[Category: Ghosh, A.]]
+
[[Category: Garcia E]]
-
[[Category: Janjua, H.]]
+
[[Category: Ghosh A]]
-
[[Category: Mills, J L.]]
+
[[Category: Janjua H]]
-
[[Category: Montelione, G T.]]
+
[[Category: Mills JL]]
-
[[Category: NESG, Northeast Structural Genomics Consortium.]]
+
[[Category: Montelione GT]]
-
[[Category: Shastry, R.]]
+
[[Category: Shastry R]]
-
[[Category: Szyperski, T.]]
+
[[Category: Szyperski T]]
-
[[Category: Xiao, R.]]
+
[[Category: Xiao R]]
-
[[Category: Zhang, Q.]]
+
[[Category: Zhang Q]]
-
[[Category: Cell junction]]
+
-
[[Category: Cell projection]]
+
-
[[Category: Endocytosis]]
+
-
[[Category: Gft nmr]]
+
-
[[Category: High throughput]]
+
-
[[Category: Human intersectin-1]]
+
-
[[Category: Membrane]]
+
-
[[Category: Nesgc]]
+
-
[[Category: Northeast structural genomics consortium]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi-2]]
+
-
[[Category: Sh3 domain]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Synapse]]
+
-
[[Category: Synaptosome]]
+

Current revision

NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.

PDB ID 2khn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2khn"
Personal tools