2i7q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2i7q" [edit=sysop:move=sysop])
Current revision (10:07, 30 August 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2i7q.png|left|200px]]
 
-
{{STRUCTURE_2i7q| PDB=2i7q | SCENE= }}
+
==Crystal structure of Human Choline Kinase A==
 +
<StructureSection load='2i7q' size='340' side='right'caption='[[2i7q]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2i7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7Q FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7q OCA], [https://pdbe.org/2i7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7q RCSB], [https://www.ebi.ac.uk/pdbsum/2i7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7q ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7q_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7q ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of Human Choline Kinase A===
+
==See Also==
-
 
+
*[[Choline kinase 3D structures|Choline kinase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[2i7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7Q OCA].
+
__TOC__
-
[[Category: Choline kinase]]
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Edwards, A M.]]
+
[[Category: Bochkarev A]]
-
[[Category: Landry, R.]]
+
[[Category: Edwards AM]]
-
[[Category: Nedyalkova, L.]]
+
[[Category: Landry R]]
-
[[Category: Park, H.]]
+
[[Category: Nedyalkova L]]
-
[[Category: Rabeh, W M.]]
+
[[Category: Park H]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Rabeh WM]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Sundstrom M]]
-
[[Category: Tempel, W.]]
+
[[Category: Tempel W]]
-
[[Category: Wasney, G.]]
+
[[Category: Wasney G]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Choline kinase]]
+
-
[[Category: Non-protein kinase]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of Human Choline Kinase A

PDB ID 2i7q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i7q"
Personal tools