This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1vpa

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:53, 20 September 2023) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1vpa.gif|left|200px]]<br /><applet load="1vpa" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1vpa, resolution 2.67&Aring;" />
 
-
'''Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TM1393) from Thermotoga maritima at 2.67 A resolution'''<br />
 
-
==About this Structure==
+
==Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TM1393) from Thermotoga maritima at 2.67 A resolution==
-
1VPA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CTP:'>CTP</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VPA OCA].
+
<StructureSection load='1vpa' size='340' side='right'caption='[[1vpa]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
-
[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[1vpa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VPA FirstGlance]. <br>
-
[[Category: Thermotoga maritima]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
-
[[Category: JCSG, Joint Center for Structural Genomics.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
[[Category: ACY]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vpa OCA], [https://pdbe.org/1vpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vpa RCSB], [https://www.ebi.ac.uk/pdbsum/1vpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vpa ProSAT], [https://www.topsan.org/Proteins/JCSG/1vpa TOPSAN]</span></td></tr>
-
[[Category: CTP]]
+
</table>
-
[[Category: MG]]
+
== Function ==
-
[[Category: 2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase]]
+
[https://www.uniprot.org/uniprot/ISPD_THEMA ISPD_THEMA] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
-
[[Category: jcsg]]
+
== Evolutionary Conservation ==
-
[[Category: joint center for structural genomics]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: protein structure initiative]]
+
Check<jmol>
-
[[Category: psi]]
+
<jmolCheckbox>
-
[[Category: structural genomics]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/1vpa_consurf.spt"</scriptWhenChecked>
-
[[Category: tm1393]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vpa ConSurf].
 +
<div style="clear:both"></div>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:37:10 2008''
+
==See Also==
 +
*[[MEP cytidylyltransferase 3D structures|MEP cytidylyltransferase 3D structures]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Thermotoga maritima]]

Current revision

Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TM1393) from Thermotoga maritima at 2.67 A resolution

PDB ID 1vpa

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vpa"
Personal tools