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2h2n

From Proteopedia

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[[Image:2h2n.png|left|200px]]
 
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{{STRUCTURE_2h2n| PDB=2h2n | SCENE= }}
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==Crystal structure of human soluble calcium-activated nucleotidase (SCAN) with calcium ion==
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<StructureSection load='2h2n' size='340' side='right'caption='[[2h2n]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal structure of human soluble calcium-activated nucleotidase (SCAN) with calcium ion===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2h2n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H2N FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16835225}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h2n OCA], [https://pdbe.org/2h2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h2n RCSB], [https://www.ebi.ac.uk/pdbsum/2h2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h2n ProSAT]</span></td></tr>
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[[2h2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H2N OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/CANT1_HUMAN CANT1_HUMAN] Desbuquois syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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<ref group="xtra">PMID:016835225</ref><references group="xtra"/>
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== Function ==
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[https://www.uniprot.org/uniprot/CANT1_HUMAN CANT1_HUMAN] Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.<ref>PMID:12234496</ref> <ref>PMID:15248776</ref> <ref>PMID:22539336</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/2h2n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h2n ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nucleoside-diphosphatase]]
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[[Category: Large Structures]]
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[[Category: Herr, A B.]]
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[[Category: Herr AB]]
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[[Category: Horii, K.]]
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[[Category: Horii K]]
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[[Category: Kirley, T L.]]
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[[Category: Kirley TL]]
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[[Category: Yang, M.]]
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[[Category: Yang M]]
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[[Category: Calcium-binding protein]]
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[[Category: Five-blade beta propeller]]
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[[Category: Hydrolase]]
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[[Category: Nucleotidase]]
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[[Category: Nucleotide-binding]]
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Current revision

Crystal structure of human soluble calcium-activated nucleotidase (SCAN) with calcium ion

PDB ID 2h2n

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