2k9d

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[[Image:2k9d.png|left|200px]]
 
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{{STRUCTURE_2k9d| PDB=2k9d | SCENE= }}
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==Solution structure of the domain X of measle phosphoprotein==
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<StructureSection load='2k9d' size='340' side='right'caption='[[2k9d]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k9d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9d OCA], [https://pdbe.org/2k9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9d RCSB], [https://www.ebi.ac.uk/pdbsum/2k9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PHOSP_MEASE PHOSP_MEASE] Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/2k9d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k9d ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In this paper we investigate the interaction between the C-terminal domains of the measles virus phosphoprotein (XD) and nucleoprotein (N(TAIL)) by using nuclear magnetic resonance chemical shift perturbation experiments. Using both N(TAIL) constructs and peptides, we show that contrary to the conserved Box2 region (N(489-506)), the C-terminal region of N(TAIL) (N(513-525)) does not directly interact with XD, and yet affects binding to XD. We tentatively propose a model where the C-terminus of N(TAIL) would stabilize the N(TAIL)-XD complex either via a functional coupling with N(489-506) or by reducing the entropic penalty associated to the binding-coupled-to-folding process.
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===Solution structure of the domain X of measle phosphoprotein===
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Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR.,Bernard C, Gely S, Bourhis JM, Morelli X, Longhi S, Darbon H FEBS Lett. 2009 Apr 2;583(7):1084-9. Epub 2009 Mar 9. PMID:19275899<ref>PMID:19275899</ref>
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{{ABSTRACT_PUBMED_19275899}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2k9d" style="background-color:#fffaf0;"></div>
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[[2k9d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Measles_virus Measles virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9D OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019275899</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Measles virus]]
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[[Category: Large Structures]]
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[[Category: Bernard, C.]]
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[[Category: Measles morbillivirus]]
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[[Category: Bourhis, J M.]]
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[[Category: Bernard C]]
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[[Category: Darbon, H.]]
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[[Category: Bourhis JM]]
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[[Category: Gely, S.]]
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[[Category: Darbon H]]
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[[Category: Longhi, S.]]
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[[Category: Gely S]]
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[[Category: Measle]]
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[[Category: Longhi S]]
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[[Category: Morbillivirus]]
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[[Category: Phosphoprotein]]
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[[Category: Rna editing]]
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[[Category: Rna replication]]
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[[Category: Viral protein]]
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[[Category: X domain]]
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Current revision

Solution structure of the domain X of measle phosphoprotein

PDB ID 2k9d

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