2gf7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2gf7" [edit=sysop:move=sysop])
Current revision (09:27, 14 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2gf7.png|left|200px]]
 
-
{{STRUCTURE_2gf7| PDB=2gf7 | SCENE= }}
+
==Double tudor domain structure==
 +
<StructureSection load='2gf7' size='340' side='right'caption='[[2gf7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2gf7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GF7 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gf7 OCA], [https://pdbe.org/2gf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gf7 RCSB], [https://www.ebi.ac.uk/pdbsum/2gf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gf7 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/2gf7_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gf7 ConSurf].
 +
<div style="clear:both"></div>
-
===Double tudor domain structure===
+
==See Also==
-
 
+
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
-
{{ABSTRACT_PUBMED_16601153}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[2gf7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GF7 OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:016601153</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bedford, M T.]]
+
[[Category: Large Structures]]
-
[[Category: Fang, J.]]
+
[[Category: Bedford MT]]
-
[[Category: Huang, Y.]]
+
[[Category: Fang J]]
-
[[Category: Xu, R M.]]
+
[[Category: Huang Y]]
-
[[Category: Zhang, Y.]]
+
[[Category: Xu RM]]
-
[[Category: Double tudor domain]]
+
[[Category: Zhang Y]]
-
[[Category: Jmjc domain containing]]
+
-
[[Category: Metal binding protein]]
+
-
[[Category: Trimethyl hisone demethylase]]
+
-
[[Category: Trimethyl histone h3 lysine 4]]
+
-
[[Category: Tudor tandem]]
+

Current revision

Double tudor domain structure

PDB ID 2gf7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gf7"
Personal tools