2kmj
From Proteopedia
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| - | [[Image:2kmj.png|left|200px]] | ||
| - | + | ==High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry== | |
| + | <StructureSection load='2kmj' size='340' side='right'caption='[[2kmj]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2kmj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZUK:5-PYRIMIDIN-2-YL-D-NORVALINE'>ZUK</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmj OCA], [https://pdbe.org/2kmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmj RCSB], [https://www.ebi.ac.uk/pdbsum/2kmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge. | ||
| - | + | Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.,Ferner J, Suhartono M, Breitung S, Jonker HR, Hennig M, Wohnert J, Gobel M, Schwalbe H Chembiochem. 2009 Jun 15;10(9):1490-4. PMID:19444830<ref>PMID:19444830</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2kmj" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
[[Category: Human immunodeficiency virus 2]] | [[Category: Human immunodeficiency virus 2]] | ||
| - | [[Category: Breitung | + | [[Category: Large Structures]] |
| - | [[Category: Ferner | + | [[Category: Breitung S]] |
| - | [[Category: Goebel | + | [[Category: Ferner J]] |
| - | [[Category: Hennig | + | [[Category: Goebel M]] |
| - | [[Category: Jonker | + | [[Category: Hennig M]] |
| - | [[Category: Schwalbe | + | [[Category: Jonker HRA]] |
| - | [[Category: Suhartono | + | [[Category: Schwalbe H]] |
| - | [[Category: Woehnert | + | [[Category: Suhartono M]] |
| - | + | [[Category: Woehnert J]] | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry
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