2kup

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[[Image:2kup.png|left|200px]]
 
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{{STRUCTURE_2kup| PDB=2kup | SCENE= }}
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==Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK==
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<StructureSection load='2kup' size='340' side='right'caption='[[2kup]]' scene=''>
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===Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KUP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20454865}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kup OCA], [https://pdbe.org/2kup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kup RCSB], [https://www.ebi.ac.uk/pdbsum/2kup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kup ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2kup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUP OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/FRS3_HUMAN FRS3_HUMAN] Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.<ref>PMID:15094036</ref>
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:020454865</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/2kup_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kup ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: Li, H.]]
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[[Category: Koshiba S]]
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[[Category: Yokoyama, S.]]
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[[Category: Li H]]
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[[Category: Complex]]
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[[Category: Yokoyama S]]
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[[Category: Halk]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Ptb domain]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Signaling protein]]
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[[Category: Signaling protein-oncoprotein complex]]
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[[Category: Snt-2]]
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[[Category: Structural genomic]]
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Current revision

Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK

PDB ID 2kup

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OCA

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