2k28

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[[Image:2k28.png|left|200px]]
 
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{{STRUCTURE_2k28| PDB=2k28 | SCENE= }}
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==Solution NMR structure of the chromo domain of the chromobox protein homolog 4==
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<StructureSection load='2k28' size='340' side='right'caption='[[2k28]]' scene=''>
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===Solution NMR structure of the chromo domain of the chromobox protein homolog 4===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k28]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K28 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k28 OCA], [https://pdbe.org/2k28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k28 RCSB], [https://www.ebi.ac.uk/pdbsum/2k28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k28 ProSAT]</span></td></tr>
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[[2k28]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K28 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CBX4_HUMAN CBX4_HUMAN] E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression.<ref>PMID:12679040</ref> <ref>PMID:16061479</ref> <ref>PMID:17018294</ref> <ref>PMID:21282530</ref> <ref>PMID:22825850</ref> Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.<ref>PMID:12679040</ref> <ref>PMID:16061479</ref> <ref>PMID:17018294</ref> <ref>PMID:21282530</ref> <ref>PMID:22825850</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k28_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k28 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M.]]
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[[Category: Bountra C]]
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[[Category: Fares, C.]]
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[[Category: Edwards AM]]
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[[Category: Gutmanas, A.]]
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[[Category: Fares C]]
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[[Category: Kaustov, L.]]
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[[Category: Gutmanas A]]
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[[Category: Lemak, A.]]
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[[Category: Kaustov L]]
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[[Category: Loppnau, P.]]
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[[Category: Lemak A]]
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[[Category: Min, J.]]
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[[Category: Loppnau P]]
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[[Category: Quyang, H.]]
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[[Category: Min J]]
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[[Category: Ravichandran, M.]]
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[[Category: Quyang H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Ravichandran M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Alpha/beta protein]]
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[[Category: Chromatin regulator]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Repressor]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Ubl conjugation pathway]]
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Current revision

Solution NMR structure of the chromo domain of the chromobox protein homolog 4

PDB ID 2k28

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