2ose

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[[Image:2ose.png|left|200px]]
 
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{{STRUCTURE_2ose| PDB=2ose | SCENE= }}
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==Crystal Structure of the Mimivirus Cyclophilin==
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<StructureSection load='2ose' size='340' side='right'caption='[[2ose]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ose]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mimivirus Mimivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OSE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ose FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ose OCA], [https://pdbe.org/2ose PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ose RCSB], [https://www.ebi.ac.uk/pdbsum/2ose PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ose ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPIL_MIMIV PPIL_MIMIV]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2ose_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ose ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Although multiple viruses utilize host cell cyclophilins, including severe acute respiratory syndrome (SARS) and human immunodeficiency virus type-1(HIV-1), their role in infection is poorly understood. To help elucidate these roles, we have characterized the first virally encoded cyclophilin (mimicyp) derived from the largest virus discovered to date (the Mimivirus) that is also a causative agent of pneumonia in humans. Mimicyp adopts a typical cyclophilin-fold, yet it also forms trimers unlike any previously characterized homologue. Strikingly, immunofluorescence assays reveal that mimicyp localizes to the surface of the mature virion, as recently proposed for several viruses that recruit host cell cyclophilins such as SARS and HIV-1. Additionally mimicyp lacks peptidyl-prolyl isomerase activity in contrast to human cyclophilins. Thus, this study suggests that cyclophilins, whether recruited from host cells (i.e. HIV-1 and SARS) or virally encoded (i.e. Mimivirus), are localized on viral surfaces for at least a subset of viruses.
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===Crystal Structure of the Mimivirus Cyclophilin===
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Structural, biochemical, and in vivo characterization of the first virally encoded cyclophilin from the Mimivirus.,Thai V, Renesto P, Fowler CA, Brown DJ, Davis T, Gu W, Pollock DD, Kern D, Raoult D, Eisenmesser EZ J Mol Biol. 2008 Apr 18;378(1):71-86. Epub 2007 Aug 29. PMID:18342330<ref>PMID:18342330</ref>
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{{ABSTRACT_PUBMED_18342330}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2ose" style="background-color:#fffaf0;"></div>
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[[2ose]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mimivirus Mimivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSE OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018342330</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Mimivirus]]
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[[Category: Large Structures]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Eisenmesser, E Z.]]
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[[Category: Raoult, D.]]
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[[Category: Renesto, P.]]
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[[Category: Thai, V.]]
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[[Category: Cyclophilin]]
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[[Category: Isomerase]]
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[[Category: Mimivirus]]
[[Category: Mimivirus]]
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[[Category: Eisenmesser EZ]]
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[[Category: Raoult D]]
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[[Category: Renesto P]]
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[[Category: Thai V]]

Current revision

Crystal Structure of the Mimivirus Cyclophilin

PDB ID 2ose

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