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2pkd

From Proteopedia

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[[Image:2pkd.png|left|200px]]
 
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{{STRUCTURE_2pkd| PDB=2pkd | SCENE= }}
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==Crystal structure of CD84: Insite into SLAM family function==
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<StructureSection load='2pkd' size='340' side='right'caption='[[2pkd]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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===Crystal structure of CD84: Insite into SLAM family function===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2pkd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PKD FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17563375}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.043&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pkd OCA], [https://pdbe.org/2pkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pkd RCSB], [https://www.ebi.ac.uk/pdbsum/2pkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pkd ProSAT]</span></td></tr>
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[[2pkd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKD OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/SLAF5_HUMAN SLAF5_HUMAN] Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.<ref>PMID:11564780</ref> <ref>PMID:12115647</ref> <ref>PMID:12928397</ref> <ref>PMID:12962726</ref> <ref>PMID:16037392</ref>
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<ref group="xtra">PMID:017563375</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/2pkd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pkd ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Almo, S C.]]
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[[Category: Large Structures]]
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[[Category: Cao, E.]]
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[[Category: Almo SC]]
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[[Category: Cole, J L.]]
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[[Category: Cao E]]
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[[Category: Fedorov, A.]]
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[[Category: Cole JL]]
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[[Category: Lary, J W.]]
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[[Category: Fedorov A]]
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[[Category: Malashkevich, V N.]]
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[[Category: Lary JW]]
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[[Category: Nathenson, S G.]]
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[[Category: Malashkevich VN]]
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[[Category: Yan, Q.]]
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[[Category: Nathenson SG]]
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[[Category: Igc]]
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[[Category: Yan Q]]
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[[Category: Igv]]
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[[Category: Immunoglobulin constant]]
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[[Category: Immunoglobulin variable]]
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[[Category: Signaling lymphocyte activation molecule]]
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[[Category: Signaling protein]]
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[[Category: Slam]]
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Current revision

Crystal structure of CD84: Insite into SLAM family function

PDB ID 2pkd

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