2f77

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[[Image:2f77.png|left|200px]]
 
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{{STRUCTURE_2f77| PDB=2f77 | SCENE= }}
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==Solution structure of the R55F mutant of M-PMV matrix protein (p10)==
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<StructureSection load='2f77' size='340' side='right'caption='[[2f77]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2f77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_retrovirus_1 Simian retrovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F77 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f77 OCA], [https://pdbe.org/2f77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f77 RCSB], [https://www.ebi.ac.uk/pdbsum/2f77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f77 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_MPMV GAG_MPMV] p10 is the matrix protein. P14 is the nucleocapsid protein. p27 is the capsid protein.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/2f77_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f77 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Despite extensive data demonstrating that immature retroviral particle assembly can take place either at the plasma membrane or at a distinct location within the cytoplasm, targeting of viral precursor proteins to either assembly site still remains poorly understood. Biochemical data presented here suggest that Tctex-1, a light chain of the molecular motor dynein, is involved in the intracellular targeting of Mason-Pfizer monkey virus (M-PMV) polyproteins to the cytoplasmic assembly site. Comparison of the three-dimensional structures of M-PMV wild-type matrix protein (wt MA) with a single amino acid mutant (R55F), which redirects assembly from a cytoplasmic site to the plasma membrane, revealed different mutual orientations of their C- and N-terminal domains. This conformational change buries a putative intracellular targeting motif located between both domains in the hydrophobic pocket of the MA molecule, thereby preventing the interaction with cellular transport mechanisms.
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===Solution structure of the R55F mutant of M-PMV matrix protein (p10)===
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D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein.,Vlach J, Lipov J, Rumlova M, Veverka V, Lang J, Srb P, Knejzlik Z, Pichova I, Hunter E, Hrabal R, Ruml T Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10565-70. Epub 2008 Jul 22. PMID:18647839<ref>PMID:18647839</ref>
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{{ABSTRACT_PUBMED_18647839}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2f77" style="background-color:#fffaf0;"></div>
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[[2f77]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_retrovirus_1 Simian retrovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F77 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018647839</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Simian retrovirus 1]]
[[Category: Simian retrovirus 1]]
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[[Category: Hrabal, R.]]
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[[Category: Hrabal R]]
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[[Category: Hunter, E.]]
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[[Category: Hunter E]]
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[[Category: Lang, J.]]
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[[Category: Lang J]]
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[[Category: Lipov, J.]]
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[[Category: Lipov J]]
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[[Category: Ruml, T.]]
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[[Category: Ruml T]]
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[[Category: Rumlova, M.]]
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[[Category: Rumlova M]]
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[[Category: Srb, P.]]
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[[Category: Srb P]]
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[[Category: Veverka, V.]]
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[[Category: Veverka V]]
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[[Category: Vlach, J.]]
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[[Category: Vlach J]]
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[[Category: 4 alpha-helice]]
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[[Category: Viral protein]]
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Current revision

Solution structure of the R55F mutant of M-PMV matrix protein (p10)

PDB ID 2f77

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